Prescription Pattern of Second Generation Antipsychotics and Outcomes of Patients with Schizophrenia in an Indian Hospital


An observational study was carried out to assess the clinical characteristics of patients with schizophrenia and the treatment pattern of the disease in a tertiary care hospital of south India. A retrospective evaluation of the prescription pattern of second generation antipsychotics and the clinical outcome of patients diagnosed with Schizophrenia in a tertiary care Indian hospital. The influence of patient demographics like age, sex, family history, type of schizophrenia and treatment on the outcome of patient at the time of discharge and length of hospital stay were also evaluated. Among a total of 139 schizophrenic patients, majority were males 81 (58.27%) and the average age was 34.4 ± 11.9 y. A predominance of male patients below 40 years and females above 40 y were observed. Paranoid schizophrenia was the major subclass (63.3%). Paranoid schizophrenia was the most prevalent subclass. Second generation antipsychotics were the major class (93.5%) used, among which tablet olanzapine was prescribed maximum (54.7%). Inj. haloperidol was the major (15.8%) first generation antipsychotic used. Anxiolytics (57.5%) and anticholinergics (56.8%) were the major adjuvant drugs used. The average hospitalization period was 12.4 ± 8.4 days and majority (92.1%) improved at discharge. An overall male predominance of schizophrenia among male population, especially more in age group below 40 y and the female domination above 40 y of age was observed. Second generation antipsychotics were the major class of treatment provided among which olanzapine received maximum prescriptions. Haloperidol was the major drug used among first generation antipsychotics. For the management of schizoaffective disorders, mood stabilizers like lithium, anxiolytics like lorazepam, antidepressants like fluoxetine and sertraline were commonly prescribed. Anticholinergic like benzhexol was prescribed for controlling the extrapyramidal side effects of antipsychotics. The increasing trend of prescribing second generation antipsychotics reflect the efficacy and safety profile as compared to first generation antipsychotics. The present study revealed an increasing trend of Paranoid schizophrenia and the use of second generation antipsychotics improved outcomes like hospitalization period and clinical status at discharge.

International Journal of Mental Health & Psychiatry (IJMHP)  ISSN: 2471-4372  Journal Impact Factor: 1.575 * is a hybrid open access international journal which is distributed all over the globe. The journal provides the choice of both open access and subscription mode of publication to the authors and publishes almost all types of write-ups like research articles, review, case reports, case study, commentary, letter to editor, mini review, opinion, short communication, book review, editorials etc. The journal’s Editorial Board is composed of international experts from the related field who have committed to seeking out excellent work from a range of sources and theoretical perspectives and also to publish high-quality, thought-provoking work that will have a direct impact on clinical practice & scientific society. The journal publishes rigorous peer reviewed research & other scholarly articles which adds new knowledge to the field and has the potential to improve the lives of those affected by mental health problems.

The journal follows double blind peer review process. Manuscripts submitted by authors will be evaluated on Editorial Manager System by Editors & reviewers of particular expertise in the same field to ensure that the published articles are of high quality with accurate and reliable information & data, which reflect solid scholarship. Editors can manage the whole submission, review, revision and publishing process, however at least two independent reviewer's approval followed by the Editor is required for the acceptance of any citable manuscript.

We welcome you to be a part of our medical Journey by contributing your outstanding research work with us. A standard editorial tracking system is utilized for manuscript submission, review and tracking for quality and quick review processing, which can be securely accessed by the authors, reviewers and editors for monitoring and tracking their articles.

Media contact:

Christina White

Editorial Assistant

International Journal of Mental Health and Psychiatry

Email id:

Whatsapp No: +1-579-679-8957